Ethylene oxide (EO) esale e sebelisoa ho bolaea likokoana-hloko le ho thibela likokoana-hloko ka nako e telele 'me ke eona feela e thibelang khase ea lik'hemik'hale e tsejoang ke lefats'e e le eona e ka tšeptjoang ka ho fetisisa. Nakong e fetileng,ethylene oxidee ne e sebelisoa haholo-holo bakeng sa ho bolaea likokoana-hloko le ho thibela likokoana-hloko maemong a indasteri. Ka nts'etsopele ea mahlale a morao-rao a indasteri le theknoloji ea boits'oaro le bohlale, theknoloji ea ethylene oxide sterilization e ka sebelisoa ka mokhoa o sireletsehileng litsing tsa bongaka ho thibela lisebelisoa tse nepahetseng tsa bongaka tse tšabang mocheso le mongobo.

Litšobotsi tsa ethylene oxide

Ethylene oxideke moloko oa bobeli oa likokoana-hloko tsa lik'hemik'hale ka mor'a formaldehyde. E ntse e le e 'ngoe ea likokoana-hloko tse ntle ka ho fetisisa tse batang ebile ke setho sa bohlokoahali sa mekhoa e mene e meholo ea ho thibela mocheso o tlase.

Ethylene oxide ke motsoako o bonolo oa epoxy. Ke khase e se nang 'mala mocheso oa kamore le khatello. E boima ho feta moea 'me e na le monko o monate oa ether. Ethylene oxide e ka tuka ebile ea phatloha. Ha moea o na le 3% ho isa ho 80%ethylene oxide, ho thehoa khase e tsoakiloeng e phatlohang, e tukang kapa ea phatloha ha e pepesehetse malakabe a bulehileng. Ethylene oxide e atisa ho sebelisoa bakeng sa ho thibela likokoana-hloko le sterilization ke 400 ho 800 mg / L, e leng sebakeng se chesang le se phatlohang moeeng, kahoo e lokela ho sebelisoa ka hloko.

Ethylene oxide e ka tsoakoa le likhase tse inert tse kangcarbon dioxideka karo-karolelano ea 1:9 ho etsa motsoako o thibelang ho phatloha, o sireletsehileng bakeng sa ho bolaea likokoana-hloko le ho thibela likokoana-hloko.Ethylene oxidee ka etsa polymerize, empa ka kakaretso polymerization e lieha 'me e etsahala haholo maemong a mokelikeli. Metsoakong ea ethylene oxide e nang le carbon dioxide kapa fluorinated hydrocarbons, polymerization e etsahala butle mme li-polymers tse tiileng ha li na monyetla oa ho phatloha.

Molao-motheo oa Ethylene Oxide Sterilization

1. Alkylation

Mokhoa oa ts'ebetso oaethylene oxideka ho bolaea likokoana-hloko tse sa tšoaneng ke haholo-holo alkylation. Libaka tsa ts'ebetso ke sulfhydryl (-SH), amino (-NH2), hydroxyl (-COOH) le hydroxyl (-OH) ka limolek'hule tsa protheine le nucleic acid. Ethylene oxide e ka etsa hore lihlopha tsena li be le maikutlo a alkylation, e leng ho etsa hore li-macromolecules tsena tsa likokoana-hloko li se ke tsa sebetsa, kahoo li bolaea likokoana-hloko.

2. Thibela mosebetsi oa li-enzyme tsa likokoana-hloko

Ethylene oxide e ka thibela ts'ebetso ea li-enzyme tse fapaneng tsa likokoana-hloko tse kang phosphate dehydrogenase, cholinesterase le li-oxidase tse ling, ho sitisa ho phethoa ha mekhoa e tloaelehileng ea metabolism ea likokoana-hloko le ho lebisa lefung la bona.

3. Phello ea ho bolaea likokoana-hloko

Ka bobeliethylene oxidemetsi le khase li na le litlamorao tse matla tsa microbicidal. Ha ho bapisoa, phello ea microbicidal ea khase e matla, 'me khase ea eona e atisa ho sebelisoa ho thibela likokoana-hloko le ho thibela likokoana-hloko.

Ethylene oxide ke ntho e thibelang likokoana-hloko e matla haholo e nang le phello e matla ea ho bolaea le ho se sebetse ho 'mele ea ho ata ha baktheria, likokoana-hloko tsa baktheria, li-fungus le livaerase. Ha ethylene oxide e kopana le likokoana-hloko, empa likokoana-hloko li na le metsi a lekaneng, karabelo pakeng tsa ethylene oxide le likokoana-hloko ke mokhoa o tloaelehileng oa taelo ea pele. Lethal dose le kenyang tšebetsong likokoana-hloko tse hloekisitsoeng, 'mele oa karabelo ke mola o otlolohileng ho boleng ba semi-logarithmic.

Mefuta e fapaneng ea tšebeliso ea ethylene oxide sterilization

Ethylene oxideha e senye lintho tse sterilized mme e na le ho kenella ka matla. Lintho tse ngata tse sa lokeleng ho thibela likokoana-hloko ka mekhoa e akaretsang li ka hlajoa ka disinfected le ho hloekisoa ka ethylene oxide. E ka sebelisoa bakeng sa sterilization ea lihlahisoa tsa tšepe, endoscopes, dialyzers le disebediswa tse lahliloeng tsa bongaka, disinfection indasteri le sterilization ea masela a sa tšoaneng, lihlahisoa tsa polasetiki, le disinfection ea lintho tse sebakeng seoa mafu a tšoaetsanoang (tse kang masela a lik'hemik'hale faeba, letlalo, pampiri, litokomane, le litšoantšo tsa oli).

Ethylene oxide ha e senye lintho tse sterilized mme e na le ho kenella ka matla. Lintho tse ngata tse sa lokeleng ho thibela likokoana-hloko ka mekhoa e akaretsang li ka hlajoa ka disinfected le ho hloekisoa ka ethylene oxide. E ka sebelisoa bakeng sa sterilization ea lihlahisoa tsa tšepe, endoscopes, dialyzers le disebediswa tse lahliloeng tsa bongaka, disinfection indasteri le sterilization ea masela a sa tšoaneng, lihlahisoa tsa polasetiki, le disinfection ea lintho tse sebakeng seoa mafu a tšoaetsanoang (tse kang masela a lik'hemik'hale faeba, letlalo, pampiri, litokomane, le litšoantšo tsa oli).

Lintlha tse amang phello ea sterilization eaethylene oxide

Phello ea sterilization ea ethylene oxide e angoa ke lintlha tse ngata. E le ho finyella phello e ntle ka ho fetisisa ea ho thibela likokoana-hloko, ke feela ka ho laola lintlha tse fapa-fapaneng ka katleho moo e ka bapalang karolo ea eona ho bolaea likokoana-hloko le ho finyella morero oa eona oa ho bolaea likokoana-hloko le ho thibela likokoana-hloko. Lintlha tse ka sehloohong tse amang phello ea sterilization ke: ho tsepamisa mohopolo, mocheso, mongobo o lekanyelitsoeng, nako ea ketso, joalo-joalo.